how to do with it/what to do with it?请问有差别麼?真正会的帮解答下吧

题目

how to do with it/what to do with it?请问有差别麼?真正会的帮解答下吧
1.I don't know how to do with it.
2.I don't know what to do with it.
这两句是不是一样意思阿还是不一样(解释不错在加分)
还有这三句
3.I don't know how to make it.
4.I don't know what to make it
5.I don't know how to do it.
文法逻辑有错请告知

答案

1.I don't know how to do with it.我不知道用它如何做.
2.I don't know what to do with it.我不知道如何处理它
"如何处理":how ...和deal with搭配 或 ..what和 do with 搭配
"处理"deal with = do with
I don't know how to make it.口语 我不知如何完成它.
4.I don't know what to make it 错句 应是 I don't know what to make .
I don't know how to do it.
我不知如何做它.